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KMID : 0378019860290110070
New Medical Journal
1986 Volume.29 No. 11 p.70 ~ p.74
A Case of Cryptococcal Meningitis


Abstract
A patient with cryptococcal meningitis whose treatment was stopped for one week due to hepato-renal toxicity during combined therapy with Amphotericin B and 5-Flucytosine completely recovered after treatment was reinstituted.
The author describes a case of crytococcal meningitis diagnosed and treated at Pohang Sun-Lin Presbyterian Hospital. The patient was a male college student who had received treatment at a local clinic for high fever, severe headache and vomiting for 10 days prior to his admission to this hospital.
The cerebrospinal fluid study revealed cryptococcus and the patient was given combined treatment of Amphotericin B and 5-Flucytosine. One week after the initial treatment was begun the patient developed hepato-renal toxicity which forced the treatment to be omitted for one week. The patient was then given the same treatment after the week of rest with clearing of the cerebrospinal fluid and with clinical symptoms greatly improved and with no sign of hepato-renal toxicity.
Six weeks of treatment arrested this meningeal infection completely. The patient comes to the clinic on an out-patient basis for follow-up checks every month and to date the results of the cerebrospinal fluid studies are completely normal.
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